YAAKOV BENENSON, TAMAR PAZ-ELIZUR, RIVKA ADAR, EHUD KEINAN, ZVI LIVNEH? & EHUD SHAPIRO: Programmable and autonomous computing machine made of biomolecules
Nature 414, 430 - 434 (2001)
Arra azert ne szamitsatok, hogy ez a "gep" barmit is kiszamol. Gyakorlatilag egy Turing gep megvalositasrol van szo, amiben a HW-t restrikcios endonukleazok es ligazok adjak, az imput es a szoftver DNS. Beadod (azaz bekevered) az input DNS-t, amibol tobb tranzicios lepesen es allapotvalltozason keresztul kepes letrehozni a szinten DNS outputot. Ezzel azert nem fogtok kvekezni mostanaban.
Idemasolom az abstraktot, ha valakit erdekel el tudom kuldeni neki a cikket. (vagy idemasolhatom az egeszet is, nem hosszu, csakhat a kepek)
Devices that convert information from one form into another according to a definite procedure are known as automata. One such hypothetical device is the universal Turing machine, which stimulated work leading to the development of modern computers. The Turing machine and its special cases, including finite automata, operate by scanning a data tape, whose striking analogy to information-encoding biopolymers inspired several designs for molecular DNA computers. Laboratory-scale computing using DNA and human-assisted protocols has been demonstrated, but the realization of computing devices operating autonomously on the molecular scale remains rare. Here we describe a programmable finite automaton comprising DNA and DNA-manipulating enzymes that solves computational problems autonomously. The automaton's hardware consists of a restriction nuclease and ligase, the software and input are encoded by double-stranded DNA, and programming amounts to choosing appropriate software molecules. Upon mixing solutions containing these components, the automaton processes the input molecule via a cascade of restriction, hybridization and ligation cycles, producing a detectable output molecule that encodes the automaton's final state, and thus the computational result. In our implementation 10exp12 automata sharing the same software run independently and in parallel on inputs (which could, in principle, be distinct) in 120 [mu] l solution at room temperature at a combined rate of 10exp9 transitions per second with a transition fidelity greater than 99.8%, consuming less than 10-10 W.
